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US 11,767,319 B2Granted
Crystalline forms of a selective c-kit kinase inhibitor
AssigneeThird Harmonic Bio, Inc.
InventorsGregg F. Keaney, Leonard Walter Rozamus, Jr., Jonathan James Loughrey, Jaclyn Raeburn, Yuxiang Song
Life of this patent
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Abstract
The present disclosure relates generally to various forms and compositions of N-(5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide useful as a selective inhibitor of c-kit kinase and uses of the same in the treatment of c-kit kinase associated diseases.
Claims24
A crystalline solid form of Compound 1:
- selected from Form C, characterized as having peaks in its X-ray powder diffraction pattern at about 10.1, about 12.5, about 15.2, about 19.7, about 20.9, about 23.0, and about 25.3 degrees 2-theta;
- Form E, characterized as having peaks in its X-ray powder diffraction pattern at about 13.1, about 14.3, about 16.4, about 17.2, about 19.2, and about 24.5 degrees 2-theta;
- Form G, characterized as having peaks in its X-ray powder diffraction pattern at about 5.8, about 12.3, about 16.8, about 17.0, about 17.5, about 22.6, and about 24.6 degrees 2-theta;
- and Form H, characterized as having peaks in its X-ray powder diffraction pattern at about 12.9, about 13.2, about 14.1, about 17.9, about 24.6, about 25.4, and about 25.7 degrees 2-theta.
1 more element
A compound salt form:
- which is Compound 2:
- characterized as having peaks in its X-ray powder diffraction pattern at about 7.8, about 19.1, about 20.3, about 23.8, about 25.3, and about 27.0 degrees 2-theta.
Dependencies are inferred from the claim text.