Non-fused thiophene derivatives and their uses

A compound of formula (I):

• wherein:
• R1 represents:
• a fused arylcycloalkyl selected from the group consisting of:
• R2 represents:
• a hydrogen,
• a halogen,
• a (C1-C6)alkyl optionally substituted by at least one halogen,
• an optionally substituted aryl, or
• an optionally substituted cycloalkyl;
• R3 represents:
• a 5-10 membered ring, saturated or unsaturated selected from the group consisting of:
• an aryl optionally fused to a heterocycloalkyl,
• a heteroaryl selected from the group consisting of a pyrimidinyl, a pyrazolyl, and a benzoisoxazolyl,
• and
• a 5-10 membered bridged carbocyclyl or heterocyclyl,
• said 5-10 membered ring is optionally substituted by at least one radical selected from the group consisting of:
• a halogen,
• a (C1-C6)alkyl optionally substituted by at least one halogen, or by an optionally bridged heterocycloalkyl optionally substituted by a (C1-C6)alkyl,
• a —NH—(C1-C6)alkyl or a —N—((C1-C6)alkyl)2, optionally substituted by at least one radical selected from the group consisting of a heterocycloalkyl, a cycloalkyl, a hydroxyl, a thiacycloalkyl-1,1dioxide and a (C1-C6)alkyloxy,
• a —NH-heterocycloalkyl, a —NH-cycloalkyl, a —N((C1-C6)alkyl)-heterocycloalkyl, or a —NH((C1-C6)alkyl)-thiacycloalkyl-1,1dioxide, optionally substituted by a hydroxyl, a (C1-C6)alkyl, a (C1-C6)alkyloxy or a —CO—R6 with R6 being a hydrogen or a (C1-C6)alkyl,
• a hydroxy, a —CN, a —CO—R6 or a —CO2R6 with R6 being a hydrogen or a (C1-C6)alkyl,
• a (C1-C6)alkyloxy optionally substituted by at least one radical selected from the group consisting of a halogen, a hydroxy, a (C1-C6)alkyloxy, a —NR7R8 with R7 and R8 are independently a hydrogen or a (C1-C6)alkyl, a —NHCOR9, a —NHCO2R9, with R9 being a (C1-C6)alkyl, a —CO2R6 with R6 being a hydrogen or a (C1-C6)alkyl, and a heterocycle,
• a —NHCOR9, a —NHCO2R9, or a —SO2R9, with R9 being a (C1-C6)alkyl, and
• a heterocycloalkyl, a bridged heterocycloalkyl, a heterocycloalkyloxy, a cycloalkyloxy, a thiaheterocycloalkyl-1,1-dioxide or a spiroheterocycloalkyl, optionally substituted by a (C1-C6)alkyl, a (C1-C6)alkyloxy, a hydroxy, a ketone, a halogen or a (C1-C6)alkyl optionally substituted by a (C1-C6)alkyloxy;
• R4 represents:
• a —CO2R10 with R10 being a hydrogen;
• and
• R5 represents:
• a hydrogen, or
• a (C1-C6)alkyl optionally substituted by at least one halogen
• and stereoisomers and pharmaceutical salts thereof.