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US 11,767,313 B2Granted
Compounds as nuclear transport modulators and uses thereof
AssigneeXwpharma Ltd.
InventorsJia-Ning Xiang, Zude Qi, Xianbo Liu, Dezheng Ning
Life of this patent
Estimating the term…
Abstract
Nuclear transport modulators are disclosed. The compounds can inhibit nuclear transporters such as the exportin-1 transporter. The compounds and pharmaceutical compositions comprising the compounds can be used to treat neurological diseases and cancer.
Claims19
A compound selected from:
- I
- (Z)-3-(3-(3- (pentafluoro-sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)- N′-(pyrazin-2- yl)acrylohydrazide
- II
- (Z)-3-(3-(3- (pentafluoro-sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)- N′-(pyridin-2- yl)acrylohydrazide
- III
- (Z)-3-(3-(3- (pentafluoro-sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)-N′- pivaloyl- acrylohydrazide
- IV
- (E)-3-(3-(3- (pentafluoro-sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)-2 -(pyrimidin-5- yl)acrylamide
- VI
- (Z)-3-(3-(3- (pentafluoro- sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)- N′-(thiazol-2- yl)acrylohydrazide
- VII
- (Z)-N′-(3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1- yl)acryloyl) cyclopropane- carbohydrazide
- VIII
- (Z)-N′-isobutyryl-3- (3-(3-(pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- IX
- (Z)-N′-(3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)acryloyl) butyrohydrazide
- X
- (Z)-N′-(3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1- yl)acryloyl) cyclobutane- carbohydrazide
- XI
- (Z)-1-methyl-N′-(3- (3-(3-(pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)acryloyl) cyclopropane-1- carbohydrazide
- XII
- (Z)-N′-(3-chloro-2- (hydroxymethyl)- 2-methylpropanoyl)-3- (3-(3-(pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- or a pharmaceutically acceptable salt of any of the foregoing.
20 more elements
A compound selected from:
- XIII
- (Z)-3-methyl- N′-(3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl)acryloyl) butanehydrazide
- XIV
- (Z)-N′-acetyl-3- (3-(3-(pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- XV
- (Z)-3-(3-(3- (pentafluoro- sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H- 1,2,4-triazol- 1-yl)-N′- propionyl- acrylohydrazide
- XVI
- (Z)-N′-(3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1yl)acryloyl)- cyclopentane- carbohydrazide
- XVII
- (Z)-N′-(2-methyl- 2-(methyl- d3)propanoyl- 3,3,3-d3)-3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- XVIII
- (Z)-3-(3-(3- (difluoromethyl)-5- (pentafluoro- sulfaneyl)phenyl)-1H- 1,2,4-triazol-1- yl)-N′-(pyrazin-2- yl)acrylohydrazide
- XIX
- (Z)-3-(3-(3- (difluoromethyl)-5- (pentafluoro- sulfaneyl)phenyl)-1H- 1,2,4-triazol-1- yl)-N′-(pyridin-2- yl)acrylohydrazide
- XX
- (Z)-3-(3-(3- (difluoromethyl)-5- (pentafluoro- sulfaneyl)phenyl)-1H- 1,2,4-triazol-1-yl)-N′- pivaloylacrylo- hydrazide
- XXI
- (Z)-3-(3-(3- (pentafluoro- sulfaneyl)- 5-(trifluoromethyl) phenyl)-1H- 1,2,4-triazol-1-yl)- N′-(pyridazin-3- yl)acrylohydrazide
- XXII
- (Z)-N′-(2-hydroxy-2- methylpropanoyl)- 3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- XXIII
- (Z)-N′-(2-fluoro-2- methylpropanoyl)- 3-(3-(3- (pentafluoro- sulfaneyl)-5- (trifluoromethyl) phenyl)-1H-1,2,4- triazol-1-yl) acrylohydrazide
- or a pharmaceutically acceptable salt of any of the foregoing.
20 more elements
Dependencies are inferred from the claim text.