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US 11,767,309 B2Granted
Methods of synthesizing substituted pyridinone-pyridinyl compounds
AssigneeAclaris Therapeutics, Inc.
InventorsGary A. Decrescenzo, John Robert Springer
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Abstract
The present disclosure provides methods of synthesizing a compound of Formula (P)-I. The method proceeds through several different pathways including several novel chiral separations, a Sonogashira coupling, a zinc mediated reductive cyanation, as well as through various halide containing intermediates. Also disclosed is the multi-kilogram preparation of several novel intermediates.
Claims36
A process for the preparation of compound of Formula (P)-I having the structure:
- comprising the steps of:
- (a) contacting a compound
- with a compound
- in the presence of dimethylacetamide (DMAc) to form a mixture;
- and
- (b) contacting the mixture of (a) with an alcoholic HCl solution
- to form a compound
- (c) converting CPD-01 to Formula (P)-I.
5 more elements
A compound, or a salt thereof, or a co-crystal thereof, selected from the group consisting of:
Dependencies are inferred from the claim text.