Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections

A method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection, said method comprising:

• administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof
• wherein R1 is independently selected from the group consisting of amine, amide, C1-C23 alkyl, aryl, heteroaryl, carbocycle, heterocycle, halogen, trifluoromethyl, and hydrogen;
• R2 is independently selected from the group consisting of trihalomethane, hydrogen, nitrogen oxide, amine, amide, and alkyl;
• R3 is independently selected from the group consisting of halogen, hydrogen, nitrogen oxide, and sulfur;
• R4 is halogen or hydrogen;
• R5 is halogen or hydrogen;
• and
• R6 is nitrogen oxide or hydrogen;
• R8 is hydrogen, halogen, or trihalomethane;
• R9 is halogen or hydrogen;
• X1, X2, and X3 are independently selected from C and N;
• wherein R2 and R3 may optionally form a heterocycle comprising one or more sulfur oxide;
• and
• wherein R1 is not hydrogen when R2 is NO2, R3 is hydrogen, R4 is chlorine, R5 is chlorine, R6 is hydrogen, R8 is hydrogen, and R9 is hydrogen, under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.