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US 11,767,296 B2Granted
Heteroaryl compounds as kinase inhibitor
AssigneeFujian Haixi Pharmaceuticals Co., Ltd
InventorsYan Feng, Ruyong Wang, Junqing Li, Jianjia Zheng, Xin Lian, Xuan Gong, Yueli Fu, Xinshan Kang
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Abstract
Provided herein are compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R1, R2, R3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.
Claims10
A compound of Formula (Ib):
- wherein
- R3 is selected from H, halogen, C6-C10 phenyl, 5-10 membered heteroaryl, C3-C6 heterocycloalkyl;
- the hydrogens in R3 are optionally substituted by one or more R7 groups independently, and the adjacent R7 groups can join to form a 5-7 membered ring;
- W is selected from C6-C10 aryl, 5-10 membered heteroaryl, wherein the hydrogens on the rings may be substituted by one or more R7 groups independently;
- R7 is selected from H, halogen, OH, NO2, CN, O(C1-C3)alkyl, (C1-C5)heteroalkyl, O(C3-C6)cycloalkyl, O(C3-C6)heterocycloalkyl, C1-C5 alkyl, C═C, C≡C, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, NR5R6, C(O)(C1-C2)alkyl, C(O)O(C1-C2)alkyl, P(O)((C1-C2)alkyl)2, SO2 cyclopropyl, S(O)n(C1-C3)alkyl, wherein n=0, 1, or 2;
- and the two adjacent R7 groups can join to form a 5-7 membered ring;
- Each R5 and R6 is independently selected from H, C1-C3 alkyl, C3-C6 cycloalkyl, C(O)C1-C3 alkyl, S(O)2(C1-C3)alkyl or S(O)2(C3-C6)cycloalkyl;
- R5 and R6 can join to form a 3-6 membered ring.
5 more elements
Dependencies are inferred from the claim text.