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US 11,767,295 B2Granted
Isoindole derivative
AssigneeTianjin Hemay Pharmaceutical Co., Ltd.
InventorHesheng Zhang
Life of this patent
Estimating the term…
Abstract
Disclosed is a compound of formula (I) and a stereoisomer thereof: wherein R1, R2, R3 and R4 are as defined in the present disclosure.
Claims29
A compound of formula (II),
- or a stereoisomer or pharmaceutically acceptable salt thereof, wherein
- R1 represents one or more identical or different substituents selected from the group consisting of optionally substituted hydrocarbylcarbonylamino, optionally substituted hydrocarbylcarbonyloxy and optionally substituted hydrocarbyloxycarbonylamino;
- R2 is hydrocarbyloxycarbonyl;
- R3 is selected from the group consisting of hydrogen, halogen, hydroxy, optionally substituted hydrocarbyloxy, optionally substituted arylhydrocarbyloxy and optionally substituted cyclohydrocarbyloxy;
- R4 is selected from the group consisting of hydrogen, halogen, hydroxy, optionally substituted hydrocarbyloxy, optionally substituted arylhydrocarbyloxy and optionally substituted cyclohydrocarbyloxy;
- and
- X is —CR5R6—, wherein
- R5 is selected from the group consisting of hydrogen, halogen, optionally substituted hydrocarbyl, optionally substituted cyclohydrocarbyl, optionally substituted aryl and optionally substituted heteroaryl, R6 is selected from the group consisting of hydrogen, halogen, optionally substituted hydrocarbyl, optionally substituted cyclohydrocarbyl, optionally substituted aryl and optionally substituted heteroaryl, and n is 0, 1, 2, 3 or 4;
- or
- R5 and R6 together with the carbon atom to which they are attached form an optionally substituted cyclohydrocarbyl, and n is 1.
7 more elements
A compound, selected from the group consisting of:
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3,4-dimethoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3,4-diethoxyphenyl)propionate;
- ethyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl (R)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl (S)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- propyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- isopropyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- butyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-(2-chloroacetamino)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-(2-(dimethylamino)acetamido)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-(2-hydroxyacetamido)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-isopropoxyphenyl)propionate;
- methyl 3-(4-fluoro-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-cyclopentyloxyphenyl)propionate;
- methyl 3-(4-methyl-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(5-fluoro-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4,7-dichloro-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-(N-methylacetamido)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(5-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-(benzyloxy)-4-methoxyphenyl)propionate;
- methyl 3-(4-(N-methyl-tert-butoxycarbonylamino)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-propoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-cyclopentyloxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-propoxyphenyl)propionate;
- methyl 3-(4-hydroxy-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetoxy-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-hydroxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-(benzyloxy)phenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-hydroxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-methoxy-4-(benzyloxy)phenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-methoxy-4-hydroxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-phenylpropionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-chlorophenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(4-ethoxypheny)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(4-chlorophenyl)propionate;
- methyl 3-(4-(tert-butyloxycarbonylamino)-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-isopropoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(4-(difluoromethoxy)-3-ethoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-(trifluoromethoxy)phenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-(difluoromethoxy)-4-methoxyphenyl))propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(4-methoxy-3-(trifluoromethoxy)phenyl)propionate;
- ethyl (R)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- ethyl (S)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propionate;
- methyl (R)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-isopropoxy-4-methoxyphenyl)propionate;
- methyl (S)-3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(3-isopropoxy-4-methoxyphenyl)propionate;
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(benzo[d][1,3]dioxol-5-yl)propionate;
- and
- methyl 3-(4-acetamido-1,3-dioxoisoindolin-2-yl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propionate,
- or a stereoisomer or pharmaceutically acceptable salts thereof.
47 more elements
Dependencies are inferred from the claim text.