US 11,766,823 B2Granted

High speed 3D printing system for wound and tissue replacement

AssigneeUniversity of Florida Research Foundation, Inc.

InventorsThomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez

Life of this patent

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Abstract

A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

Claims10

Dependent claims

A system for creating a three-dimensional tissue construct of a desired shape for repair or replacement of tissue of a tissue cavity of an organism, the system comprising and apparatus and a support material:

wherein the apparatus comprises an injector configured to inject at least one biomaterial in a three-dimensional pattern into the support material such that the at least one biomaterial is held in the desired shape of the tissue construct by the support material,
wherein the support material comprises a Herschel-Bulkley material comprising a soft granular gel made from crosslinked polymeric packed microparticles swelled with a liquid culture medium,
wherein the soft granular gel exists in a solid phase with a modulus of from 100 to 300 Pa and having a yield stress less than 100 Pascals, and
wherein the soft granular gel undergoes a phase change from the solid phase to a liquid phase upon application of a shear stress greater than the yield stress.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 17/233,626Filed 19 Apr 2021 · continuation
Priority: 13 Feb 2015
Published: US 2021/0252777 A119 Aug 2021
Granted: 26 Sep 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification37 codes

B29C 64/118
Using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material: using filamentary material being melted, e.g.…
A61F 2/30942
Designing or manufacturing processes: for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element…
A61L 27/16
Macromolecular materials: obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/18
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Family

Application62/116,351Us provisional application · filed 13 Feb 2015
PCT/US2016/017810Parent of this continuation · filed 12 Feb 2016
US 2021/0252777 A1Pre-grant publication · published 19 Aug 2021
Application15/549,083Parent of this continuation
US 11,007,705 B2Parent of this continuation
US 2018/0021140 A1Published application
US 11,766,823 B2This patent

From the US filing history. Foreign family members aren’t listed.