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US 11,766,511 B2Granted
Antithrombogenic hollow fiber membranes and filters
AssigneeInterface Biologics, Inc.
InventorsSanjoy Mullick, Weilun Chang, Hanje Chen, Mark A. Steedman, Roseita Esfand
Life of this patent
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Abstract
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
Claims13
An extracorporeal blood circuit comprising a blood tubing and an array of hollow fiber membranes, wherein the blood tubing, the hollow fiber membranes, or both comprise a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule described by formula (VII):
- FT—[B—(Oligo)]n—B—FT, (VII),
- wherein
- (i) Oligo is polypropylene oxide having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is a hard segment formed from hexamethylene diisocyanate;
- (iii) FT is a polyfluoroorgano group;
- and
- (iv) n is an integer from 1 to 10.
4 more elements
A dialysis kit comprising a hollow fiber membrane, a potted bundle, a dialysis filter, and/or blood tubing, wherein one or more of the hollow fiber membrane, potted bundle, dialysis filter, and/or blood tubing comprises a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule described by formula (VII):
- FT—[B—(Oligo)]n—B—FT, (VII),
- wherein
- (i) Oligo is polypropylene oxide having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is a hard segment formed from hexamethylene diisocyanate;
- (iii) FT is a polyfluoroorgano group;
- and
- (iv) n is an integer from 1 to 10.
4 more elements
A potted bundle of hollow fiber membranes within an encasement comprising:
- (a) an array of hollow fiber membranes, said array of hollow fiber membranes having lumens, a first set of fiber ends, and a second set of fiber ends;
- (b) said first set of fiber ends being potted in a potting resin which defines a first internal wall near a first end of the encasement;
- and
- (c) said second set of fiber ends being potted in a potting resin which defines a second internal wall near a second end of the encasement,
- wherein said lumens of said hollow fiber membranes provide a path for the flow of blood from said first internal wall to said second internal wall,
- wherein said potting resin comprises from 0.005% to 10% (w/w) surface modifying macromolecule, and wherein said surface modifying macromolecule is described by:
- (1)
- FT—(oligo)—FT (I)
- wherein FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da and oligo is an oligomeric segment;
- or
- wherein
- (i) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da covalently attached to LinkB;
- (ii) C is a chain terminating group;
- (iii) Oligo is an oligomeric segment;
- (iv) LinkB is a coupling segment;
- and
- (v) a is an integer greater than 0;
- or
- (3)
- FT—[B—(oligo)]n—B—FT (III)
- wherein
- (i) B comprises a urethane;
- (ii) oligo comprises polypropylene oxide, polyethylene oxide, or polytetramethylene oxide;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 1 to 10;
- or
- (4)
- FT—[B—A]n—B—FT (IV)
- wherein
- (i) A comprises hydrogenated polybutadiene, poly (2,2 dimethyl-1,3-propylcarbonate), polybutadiene, poly (diethylene glycol)adipate, poly (hexamethylene carbonate), poly (ethylene-co-butylene), neopentyl glycol-ortho phthalic anhydride polyester, diethylene glycol-ortho phthalic anhydride polyester, 1,6-hexanediol-ortho phthalic anhydride polyester, or bisphenol A ethoxylate;
- (ii) B comprises a urethane;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da, and
- (iv) n is an integer from 1 to 10;
- or
- wherein
- (i) A comprises hydrogenated polybutadiene (HLBH), poly (2,2 dimethyl-1,3-propylcarbonate) (PCN), polybutadiene (LBHP), polytetramethylene oxide (PTMO), polypropylene oxide (PPO), diethyleneglycol-orthophthalic anhydride polyester (PDP), hydrogenated polyisoprene (HHTPI), poly(hexamethylene carbonate), poly(2-butyl-2-ethyl-1,3-propyl carbonate), or hydroxylterminated polydimethylsiloxane (C22);
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) each FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer between 0 to 10;
- or
- (6)
- FT-[B-(Oligo)]n—B—FT (VII)
- wherein
- (i) Oligo is an oligomeric segment comprising polypropylene oxide, polyethylene oxide, or polytetramethyleneoxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is formed from 3-isocyanatomethyl, 3,5,5-trimethyl cyclohexylisocyanate;
- 4,4′-methylene bis(cyclohexyl isocyanate);
- 4,4′-methylene bis(phenyl) isocyanate;
- toluene-2,4 diisocyanate;
- m-tetramethylxylene diisocyanate;
- or hexamethylene diisocyanate;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 1 to 10;
- or
- wherein
- (i) A is an oligomeric segment comprising polypropylene oxide, polyethylene oxide, polytetramethyleneoxide, or mixtures thereof, and having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 0 to 10;
- or
- (8)
- FT-[B-(Oligo)]n—B—FT (IX)
- wherein
- (i) Oligo comprises a polycarbonate polyol having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is formed from 3-isocyanatomethyl, 3,5,5-trimethyl cyclohexylisocyanate;
- 4,4′-methylene bis(cyclohexyl isocyanate);
- 4,4′-methylene bis(phenyl) isocyanate;
- toluene-2,4 diisocyanate;
- m-tetramethylxylene diisocyanate;
- or hexamethylene diisocyanate;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 1 to 10;
- or
- wherein
- (i) A is an oligomeric segment comprising a polycarbonate polyol having a theoretical molecular weight of from 500 to 3,000 Daltons;
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 0 to 10;
- or
- wherein
- (i) A comprises a first block segment selected from the group consisting of polypropylene oxide, polyethylene oxide, polytetramethyleneoxide, and mixtures thereof, and a second block segment comprising a polysiloxane or polydimethylsiloxane, wherein A has a theoretical molecular weight of from 1,000 to 5,000 Daltons;
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 0 to 10;
- or
- (11)
- FT-[B—A]n—B—FT (XII)
- wherein
- (i) A comprises hydrogenated polybutadiene (HLBH), polybutadiene (LBHP), hydrogenated polyisoprene (HHTPI), or polystyrene and has a theoretical molecular weight of from 750 to 3,500 Daltons;
- (ii) B is formed from 3-isocyanatomethyl, 3,5,5-trimethyl cyclohexylisocyanate;
- 4,4′-methylene bis(cyclohexyl isocyanate);
- 4,4′-methylene bis(phenyl) isocyanate;
- toluene-2,4 diisocyanate;
- m-tetramethylxylene diisocyanate;
- or hexamethylene diisocyanate;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 1 to 10;
- or
- wherein
- (i) A comprises hydrogenated polybutadiene (HLBH), polybutadiene (LBHP), hydrogenated polyisoprene (HHTPI), or polystyrene and has a theoretical molecular weight of from 750 to 3,500 Daltons;
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 0 to 10;
- or
- wherein
- (i) A is a polyester having a theoretical molecular weight of from 500 to 3,500 Daltons;
- (ii) B is formed by reacting a triisocyanate with a diol of A, wherein the triisocyanate is selected from the group consisting of hexamethylene diisocyanate (HDI) biuret trimer, isophorone diisocyanate (IPDI) trimer, and hexamethylene diisocyanate (HDI) trimer;
- (iii) FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da;
- and
- (iv) n is an integer from 0 to 10.
115 more elements
Dependencies are inferred from the claim text.