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US 11,766,475 B2Granted
Food safety vaccine to control Salmonella enterica and reduce Campylobacter in poultry
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsRoy Curtiss, III, Soo-Young Wanda
Life of this patent
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Abstract
Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
Claims13
A recombinant derivative of a Salmonella enterica pathogenic bacterium comprising:
- (a) a regulated-delayed attenuation conferred by a Δpmi mutation;
- (b) a regulated-delayed expression of an antigen of interest conferred by a ΔrelA::araC PBAD lacI TT deletion-insertion mutation;
- (c) a regulated-delayed lysis in vivo phenotype conferred by a ΔPmurA::TT araC PBAD murA deletion-insertion mutation and a ΔasdA::TT araC PBAD c2 deletion-insertion mutation;
- and
- (d) a nucleic acid sequence encoding one or more protein antigens of Eimeria.
2 more elements
Dependencies are inferred from the claim text.