Compositions and methods for induced brown fat differentiation
AssigneeDana-Farber Cancer Institute, Inc.
InventorsBruce M. Spiegelman, Shingo Kajimura
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Abstract
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm16 and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm16 and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm16 and C/EBPβ expression and/or activity.
Claims16
An in vitro or ex vivo method for generating brown fat cells from mammalian myoblasts and/or endogenous fibroblasts comprising expressing both PR-domain containing protein-16 (PRDM16) and CCAAT/enhancer binding protein beta (C/EBPβ) expression vector encoding PRDM16 and C/EBPβ in the myoblasts and/or fibroblasts thereby generating brown fat cells from the myoblasts and/or fibroblasts.
Dependencies are inferred from the claim text.