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US 11,766,463 B2Granted
Microorganisms engineered to reduce hyperphenylalaninemia
AssigneeSynlogic Operating Company, Inc.
InventorsKristin Adolfsen, Per Greisen, Isolde Callihan, Adam Lawrence, James Spoonamore, Jay Konieczka
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Abstract
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
Claims8
A mutant phenylalanine ammonia lyase (PAL) polypeptide comprising one or more mutations at amino acid positions selected from S92, H133, I167, L432, V470, A433, A263, K366 and L396 compared to a wildtype Photorhabdus luminescens PAL comprising SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.