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US 11,766,460 B2Granted
Pharmaceutical composition comprising amniotic fluid stem cell spheroid and the use thereof in treatment of urinary incontinence
AssigneeU-Neuron Biomedical Inc.
InventorsShiaw-Min Hwang, Shing-Hwa Lu, Kuei-Chang Li, Wei-Ti Wang
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Abstract
Disclosed herein is a use of an amniotic fluid stem cell spheroid in the preparation of a composition or pharmaceutical composition for treating urinary incontinence, wherein said pharmaceutical composition may further comprise hyaluronic acid.
Claims2
A method for the treatment of urinary incontinence with urethral sphincter deficiency, comprising administering to a subject in need thereof a pharmaceutical composition including a therapeutically effective amount of amniotic fluid stem cell spheroids and hyaluronic acid,
- wherein the pharmaceutical composition is administered by intramuscular injection to a sphincter muscle of urethra of the subject, and
- wherein the amniotic fluid stem cell spheroids are prepared by a method comprising inoculating amniotic fluid stem cells at a concentration of 1×105 cells/well on a low-adherence culture plate, and culturing overnight to obtain the amniotic fluid stem cell spheroids, each containing 100-200 cells.
Dependencies are inferred from the claim text.