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US 11,766,457 B2Granted
Immunosuppressive antigen-specific chimeric antigen receptor Treg cells for prevention and/or treatment of autoimmune and alloimmune disorders
AssigneeThe University of Toledo
InventorsJuan C. Jaume, Shahnawaz Imam
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Abstract
Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
Claims10
An immunoresponsive cell comprising:
- a chimeric antigen receptor (CAR) that binds to glutamic acid decarboxylase 65 kDA (GAD65) in the cell;
- the CAR comprising:
- a) an intracellular signaling domain of a CD3ζ polypeptide and an intracellular signaling domain of CD28 hinge-transmembrane-intracellular region, and
- b) an extracellular polypeptide comprising an amino acid sequence that is a GAD65 MAb antigen binding domain;
- wherein the extracellular polypeptide comprises SEQ ID NO:
- 7, or an amino acid sequence having at least 95% identity to SEQ ID NO:
- 7.
4 more elements
Dependencies are inferred from the claim text.