Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance
AssigneeInternational Business Machines Corporation
InventorsJames L Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Abstract
Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
Claims20
A method for treating a bacteria infection, comprising:
- contacting the bacteria infection with a combination therapy comprising an antibiotic and a polyionene polymer comprising a terephthalamide structure, wherein the polyionene polymer and the antibiotic in combination provide a synergistic antimicrobial effect comprising an enhancement in an antimicrobial activity of the antibiotic.
A method for reducing a minimum inhibitory concertation of an antibiotic in association with treating a bacteria infection of a subject, comprising:
- administering a combination therapy to the subject, the combination therapy comprising the antibiotic and a polyionene polymer comprising a terephthalamide structure, wherein the polyionene polymer and the antibiotic in combination provide a synergistic antimicrobial effect comprising an enhancement in an antimicrobial activity of the antibiotic.
A method for inhibiting a development of a resistance to an antibiotic by a bacterium, comprising:
- administering, to the bacterium, a mixture of the antibiotic and a polyionene polymer comprising a terephthalamide structure, wherein the polyionene polymer and the antibiotic in combination provide a synergistic antimicrobial effect comprising an enhancement in an antimicrobial activity of the antibiotic.
Dependencies are inferred from the claim text.