3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator

A compound of Formula (I):

• or pharmaceutically acceptable salt thereof,
• wherein
• X1 and X3 are each independently OH, OR3, SH, or SR3;
• X2 and X4 are each independently O or S;
• Y is O or CH2;
• R1a, R1b, R2a, and R2b are each independently H, OR5, NH2, or halogen;
• each R5 is independently H or C1-C6 alkyl;
• each R3 is independently C1-C6 alkyl or -L-R4;
• each R4 is independently —O(C═O)—N(R4a)2, —O(C═O)—NHR4a, —O(C═O)—R4a, or —O(C═O)—O—R4a;
• each R4a is independently C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, —(C1-C6 alkylene)-(C3-C14 cycloalkyl) or C3-C20 cycloalkyl, wherein each R4a is independently optionally substituted with 1, 2, or 3 R4b;
• each R4b is independently —OH, —SH, —NH2, ═O, ═NH, ═S, halogen, —N3, —CN, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylamino, or C1-C6 dialkylamino;
• L is L1, L1-O(C═O)-L2, L1-(C═O)O-L2, L1-O-L2, L1-S(O)n-L2, L1-O(C═O)O-L2, L1-O(C═O)NR6-L2, L1-NR6(C═O)O-L2, or L1-O(C═O)-L2-O-L3;
• L1 is C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, or C7-C13 alkylarylene;
• L2 is C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, C6-C10 arylene, or 5- to 10-membered heteroarylene;
• L3 is C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene;
• R6 is H or C1-C6 alkyl;
• n is 0, 1, or 2;
• Base1 and Base2 are each independently
• wherein
• A, A1, A2, A3 and A4 are each independently H, OH, SH, F, Cl, Br, I, NH2, OR15, SR15, NHR15, N(R15)2, or R16;
• each Z is independently O, S, or NR15;
• each R′5 is independently H, —C(═Z1)R16, —C(═Z1)OR16, —C(═Z1)SR16, —C(═Z1)N(R16)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
• each Z1 is independently O or S;
• and
• each R16 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl.