Back to results
US 11,766,446 B2Granted
Treatment of aging-associated conditions by DNA degradation
AssigneeThe General Hospital Corporation
InventorsYuk Yuen Lan, Nir Hacohen
Life of this patent
Estimating the term…
Abstract
Provided herein, in some embodiments, are methods for treating age-associated conditions, including systemic inflammation and disease, via enhanced DNA degradation.
Claims14
A method for treating an aging-associated condition in a subject, comprising:
- administering a DNase enzyme to the subject,
- wherein the aging-associated condition is a laminopathy, an interferonopathy, ataxia telangiectasia (A-T), Hutchison-Gilford progeria, or aging-associated inflammation and cellular senescence that is induced or enhanced by treatment with a chemotherapeutic agent.
A method for treating an aging-associated condition in a subject, comprising:
- identifying a subject as having elevated levels of extranuclear DNA relative to a control;
- and
- administering a DNase enzyme to the subject.
A method for treating an aging-associated condition in a subject, comprising:
- identifying a subject as having elevated levels of SA-β-gal activity relative to a control;
- and
- administering a DNase enzyme to the subject.
Dependencies are inferred from the claim text.