Methods for the prevention and treatment of hearing loss
AssigneeTing Therapeutics LLC
InventorsJian Zuo, Zhuo Li
Life of this patent
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Abstract
In one aspect, use of compounds as active agents to treat a hearing impairment and to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. Momelotinib and Fedratinib exhibit excellent protection against antibiotic-induced hearing loss in zebrafish and mice when administered prophylactically. In one aspect, Momelotinib or Fedratinib can be used as a therapy for the treatment and/or prevention of hearing loss. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims8
A method to prevent or treat hearing loss comprising:
- administering to a mammal-in need thereof an effective amount of a pharmaceutical composition containing a therapeutically active agent, wherein the therapeutically active agent is mornelotinib.
A kit comprising:
- an active agent, wherein the active agent is momelotinib or a pharmaceutically acceptable salt thereof;
- and one or more of:
- (A) at least one antibiotic;
- and (B) at least one cancer drug.
Dependencies are inferred from the claim text.