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US 11,766,439 B2Granted
Human papilloma virus as predictor of cancer prognosis
AssigneesFoundation Medicine, Inc., UCL Business PLC
InventorsChris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
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Abstract
Methods of treating a head and neck cancer are disclosed.
Claims18
A method for generating a personalized cancer treatment report, comprising:
- acquiring a sample from a subject having a squamous cell carcinoma of the head and neck (HNSCC);
- determining whether the subject is HPV− or HPV+;
- selecting a treatment based on whether the subject is HPV− or HPV+, wherein:
- (i) if the subject is HPV+, a mammalian target of rapamycin (mTOR) inhibitor, a phosphatidylinositol-3 kinase (PI3K) inhibitor, or a PI3K/mTOR inhibitor is selected as a treatment, or
- (ii) if the subject is HPV−, a CDK inhibitor is selected as a treatment;
- and
- generating the personalized cancer treatment report to memorialize the selected treatment.
4 more elements
Dependencies are inferred from the claim text.