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US 11,766,437 B2Granted
Combination therapies for inhibition of TTK protein kinase
AssigneeUniversity Health Network
InventorsMark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
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Abstract
Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
Claims13
A method for treating colon cancer, comprising:
- administering to a subject an effective amount of a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof and an effective amount of a PD-1 inhibitor.
A pharmaceutical composition comprising a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof and a PD-1 inhibitor.
Dependencies are inferred from the claim text.