Therapeutical composition containing apomorphine as active ingredient
AssigneeBritannia Pharmaceuticals Limited
InventorsMichael Dey, Joel Richard, Marie-Madeleine Baronnet, Nathalie Mondoly, Laurent Bertocchi, Jeremiah Harnett
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Abstract
A pharmaceutical composition contains apomorphine as the active pharmaceutical ingredient, a water-miscible co-solvent, an antioxidant, and water. The solution has a pH greater than 4. The pharmaceutical composition is suitable for parenteral administration for the treatment of Parkinson's disease. The process for the manufacture of the pharmaceutical composition includes weighing the apomorphine and introducing it into a container with the co-solvent and the antioxidant under agitation until complete dissolution takes place.
Claims18
A pharmaceutical composition in the form of a solution comprising:
- i) apomorphine as the active substance;
- ii) a water miscible co-solvent;
- iii) an anti-oxidant;
- and
- iv) water,
- wherein a pH of the composition is greater than 4.
Dependencies are inferred from the claim text.