US 11,766,426 B2 · Semi-solid topical composition containing pirfenidone and modified diallyl disulfide oxide (M-DDO) for eliminating or preventing acne

Abstract

The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

Claims20

Dependent claims

A semi-solid topical composition for eliminating or reducing skin acne occurrence comprising:

(i) 2-10% pirfenidone by weight;
(ii) 1% carbomer by weight;
(iii) 50% propylene glycol by weight;
(iv) 13% macrogol-glycerol hydroxystearate by weight;
(v) 0.016% {[1,2-diallyl-1-(5-methyl-tetrahydro-2H-pyran-2-yloxy)disulfonium]+6-[(benzyl, methyl, octylammonium)(hydroxymethylamin)(methylamin)]-tetrahydro-2H-pyran-3-oxy]}chloride (M-DDO) by weight;
(vi) 1% triethanolamine by weight;
and
(vii) 32.984%-24.984% water by weight.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/328,685Filed 24 May 2021 · continuation

Priority

MX MX/A/2012/00369428 Mar 2012

Published

US 2021/0346360 A111 Nov 2021

Granted

26 Sep 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 31/4412
Non condensed pyridines; Hydrogenated derivatives thereof: having oxo groups directly attached to the heterocyclic ring
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring

Family

PCT/MX2013/000027Parent of this continuation · filed 27 Feb 2013

Application15/098,970Parent of this division · filed 14 Apr 2016

Application15/920,822Parent of this continuation · filed 14 Mar 2018

Application16/534,980Parent of this continuation · filed 7 Aug 2019

US 2021/0346360 A1Pre-grant publication · published 11 Nov 2021

US 11,013,727 B2Parent of this continuation

US 9,949,959 B2Parent of this division

Application15/920,822Parent of this division

Application14/388,447Parent of this continuation

Application15/098,970Parent of this continuation

US 2015/0148382 A1Published application

US 2016/0228424 A1Published application

US 2018/0214434 A1Published application

US 2020/0061040 A1Published application

US 11,766,426 B2This patent

From the US filing history. Foreign family members aren’t listed.

Semi-solid topical composition containing pirfenidone and modified diallyl disulfide oxide (M-DDO) for eliminating or preventing acne

Life of this patent

Semi-solid topical composition containing pirfenidone and modified diallyl disulfide oxide (M-DDO) for eliminating or preventing acne

Life of this patent

Abstract

Claims20