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US 11,766,422 B2Granted
Galloylated procyanidins for treating endovascular dysfunction and increasing blood flow
AssigneesUniversity of South Florida, Encore IP Management, LLC
InventorsMichael Louis Sperduti, Matthew Cleary Nickerson, Jimmy Roy Huddleston, Leigh Anthony West
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Abstract
The present disclosure is directed to compositions, methods of use, and methods of making, wherein the compositions contain one or more galloylated procyanidins having between two and five epicatechin monomers, wherein the one or more galloylated procyanidins include epicatechin-(4-8)-epicatechin-(4-8)-epicatechin-gallate, catechin trimer gallate, catechin dimer digallate, or combinations thereof.
Claims15
A method of increasing blood flow in a subject, comprising:
- administering a composition to a subject, wherein the composition comprises:
- a therapeutically effective amount of an epigallocatechin gallate dimer and an epicatechin gallate dimer;
- and
- a pharmaceutically acceptable excipient or carrier.
1 more element
Dependencies are inferred from the claim text.