Soft gelatin capsules containing a mixture of analgesics and decongestants, expectorants, antitussives and/or antihistamines

A method of preparing a clear liquid softgel fill composition consisting of the steps of:

• a) stirring polyethylene glycol or a mixture of polyethylene glycols, and propylene glycol with heating to 70° C.±10° C. until a clear solution is obtained;
• followed by
• b) slowly adding polyvinylpyrrolidone in small quantities with continuous mixing and heating to 70° C.±10° C., until a clear solution is obtained;
• followed by
• c) adding purified water with continuous mixing and heating to 70° C.±10° C., until a clear solution is obtained;
• followed by
• d) adding acetaminophen in small quantities with continuous mixing and heating to 70° C.±10° C., until a clear solution is obtained;
• thereafter
• e) adding guaifenesin with continuous mixing and heating to 70° C.±10° C., until a clear solution is obtained;
• f) successively adding i) dextromethorphan HBr and ii) phenylephrine HCl with continuous mixing and optionally heating up to 80° C., until a clear solution is obtained;
• and
• g) cooling to ambient temperature and deaerating the clear solution from step f;
• whereby said clear liquid softgel fill composition is stable to storage for at least two years,
• wherein steps a) to g) are performed in a single container and in an order as set forth above.