Process for the preparation of a freeze-dried pharmaceutical composition containing mitomycin C
AssigneeMedac Gesellschaft FüR Klinische SpezialpräParate Mbh
InventorsSonja Schuldt-Lieb, Sebastian Bialleck, Ingo Guhde, Michaela Rehberg
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Abstract
A process is described for the preparation of freeze-dried pharmaceutical compositions of mitomycin C, which are characterized by high stability and can be rapidly reconstituted to form solutions.
Claims8
Freeze-dried pharmaceutical composition comprising mitomycin C and urea, wherein the composition comprises urea at a concentration of 0.2 to 0.99 grams (g) per gram of composition.
Freeze-dried pharmaceutical composition comprising mitomycin C, wherein the composition is obtainable by a process comprising freeze-drying a solution of mitomycin C, wherein the solution comprises a mixture of tert.-butanol and water, and wherein the mixture comprises 84 to 95 wt. % tert.-butanol.
Dependencies are inferred from the claim text.