Bioavailable dithiocarbamate-metal complex particles, method of preparation and use thereof

A molecular complex comprising a particulate form of dithiocarbamate-copper complex and at least one blood protein, wherein the blood protein is selected from the group consisting of albumin, transferrin, immunoglobulin, monoclonal immunoglobulin, whole blood, blood plasma and blood serum, wherein the particulate form is free of organic solvents, wherein the molecular complex has an average particle size in the range of 2-80 nm and is obtained by a process comprising the following steps:

• (a) combining a first component selected from dithiocarbamate and copper salt with at least one blood protein in an aqueous solvent, and
• (b) subsequently adding a second component selected from dithiocarbamate and copper salt,
• wherein if the first component is dithiocarbamate, then the second component is copper salt;
• and if the first component is copper salt, then the second component is dithiocarbamate, and
• (c) optionally lyophilizing the resulting solution;
• wherein the dithiocarbamate has a formula (R1)(R2)N—CS2—, wherein R1 and R2 are the same or different and are independently selected from the group consisting of C1—C4 alkyl and C3—C6 cycloalkyl;
• wherein the molecular complex contains the molecules of the dithiocarbamate-copper complex and the at least one blood protein bound together by non-covalent binding interactions, and wherein the molecular complex is not a core-shell particle.