Peptide-targeted liposomal delivery for treatment, diagnosis, and imaging of diseases and disorders
AssigneesUniversity of Maryland, Baltimore, The United States Government as represented by the Department of Veterans Affairs
InventorsKamal D. Moudgil, Rakeshchandra R. Meka
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Abstract
The present invention relates in part to compositions for targeted delivery of an agent and agent delivery systems comprising a novel tissue-targeting peptide ligand (CKPFDRALC) (SEQ ID NO: 1) named ART-2. In certain aspects, the ART-2-coated liposomes encapsulating an agent, such as a therapeutic agent, diagnostic agent, imaging agent, or any combination thereof, were more effective in inhibiting, diagnosing, or imaging a disease or disorder, such as an arthritis progression, than control, despite a comparable safety profile.
Claims22
A composition comprising at least one isolated peptide comprising the amino acid sequence CKPFDRALC (SEQ ID NO:
- 1), wherein the peptide selectively targets inflamed synovial tissue.
A method of delivering an agent to a biological tissue, the method comprising administering a composition to a subject in need thereof, wherein the composition comprises the agent and at least one isolated peptide comprising the amino acid sequence CKPFDRALC (SEQ ID NO:
- 1), and
- wherein the peptide selectively targets inflamed synovial tissue.
A composition for targeted delivery of an agent, the composition comprising at least one isolated peptide conjugated to a liposome, lipid, pharmaceutically acceptable carrier, or any combination thereof,
- wherein the peptide is a tissue-targeting peptide comprising the amino acid sequence CKPFDRALC (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.