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US 11,766,401 B2Granted
Methods of administering lipid formulations with immunogens
AssigneeGlaxosmithkline Biologicals SA
InventorAndrew Geall
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Abstract
RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.
Claims29
A method of eliciting an immune response against an immunogen in a human or a cow, the method comprising:
- administering to the human or the cow an immunologically effective unit dose of a formulation comprising:
- RNA molecules comprising a sequence that encodes the immunogen;
- and
- lipids comprising a tertiary amine cationic lipid, a polyethylene glycol-conjugated (PEG-conjugated) lipid, and cholesterol;
- and
- wherein the lipids encapsulate at least half of the RNA molecules and the immune response against the immunogen comprises an antibody response against the immunogen.
3 more elements
Dependencies are inferred from the claim text.