Skin care composition comprising acetylated hyaluronic acid with degree of acetylation quantified by 2D-MR
AssigneeGivaudan SA
InventorsMartin Lovchik, Gerhard Brunner, Romain Reynaud, Amandine Scandolera
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Abstract
A skin care composition comprising low molecular weight acetylated hyaluronic acid or its sodium salt having a weight average molecular weight less than 50 kDa, and a degree of acetylation of at least 3.6 is useful in the treatment of the visible effects of age on human skin.
Claims19
A skin care composition comprising low molecular weight acetylated hyaluronic acid or sodium salt thereof, wherein:
- the low molecular weight acetylated hyaluronic acid or its sodium salt has a weight average molecular weight of 50 kDa or less and an average degree of O-acetylation of greater than 3.6, wherein the degree of O-acetylation is determined by quantitative 2D NMR.
A method of preparing low molecular weight acetylated hyaluronic acid or sodium salt thereof having a weight average molecular weight of 50 kDa or less and an average degree of O-acetylation of greater than 3.6, wherein the degree of O-acetylation is determined by quantitative 2D NMR, comprising the steps of:
- (i) providing a low molecular weight hyaluronic acid having a molecular weight of 50 kDa or less;
- (ii) subjecting it to acetylation conditions:
- and, (iii) isolating the low molecular weight acetylated hyaluronic acid.
Low molecular weight acetylated hyaluronic acid or sodium salt thereof having a weight average molecular weight of 50 kDa or less and an average degree of O-acetylation of greater than 3.6, wherein the degree of O-acetylation is determined by quantitative 2D NMR, in the form of a white powder having an L* value of about 90 or more, and a b* value of less than about 8.
Dependencies are inferred from the claim text.