Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

A system for tracking coronary artery disease (CAD) based on non-invasive medical image analysis of a medical image of a subject to facilitate determination of a state of plaque progression, regression, or stabilization, the system comprising:

• one or more computer readable storage devices configured to store a plurality of computer executable instructions;
• and
• one or more hardware computer processors in communication with the one or more computer readable storage devices and configured to execute the plurality of computer executable instructions in order to cause the system to:
• access a first distribution of density values corresponding to one or more regions of plaque in one or more regions of one or more coronary arteries of a subject, wherein the first distribution of density values is generated from analyzing a first medical image of the subject comprising the one or more regions of the one or more coronary arteries, the first medical image of the subject obtained non-invasively at a first point in time;
• access a second medical image of the subject, the second medical image of the subject obtained non-invasively at a second point in time, the second point in time being later than the first point in time, the second medical image of the subject comprising the one or more regions of the one or more coronary arteries of the subject;
• identify the one or more regions of the one or more coronary arteries of the subject from the first medical image in the second medical image;
• analyze the second medical image to generate a second distribution of density values corresponding to the one or more regions of plaque in the one or more regions of the one or more coronary arteries of the subject;
• determine a change between the first distribution of density values corresponding to the one or more regions of plaque and the second distribution of density values corresponding to the one or more regions of plaque, wherein an increase in density values above a first predetermined threshold is indicative of plaque progression, wherein an increase in density values above a second predetermined threshold is indicative of plaque progression, and wherein an increase in density values above a third predetermined threshold is indicative of plaque stabilization;
• and
• generate a graphical representation comprising the determined change between the first distribution of density values corresponding to the one or more regions of plaque and the second distribution of density values corresponding to the one or more regions of plaque, wherein the graphical representation is configured to facilitate determination of a state of plaque progression, regression, or stabilization based at least in part on the determined change in total plaque volume, non-calcified plaque volume, and calcified plaque volume.