Navigational reference dislodgement detection method and system

A method of measuring electrophysiology information using multiple electrodes, comprising:

• providing a localization system that determines locations of objects within a 3-D space and generates location information data comprising position information;
• securing a local reference at an internal reference location within a patient's body, said local reference comprising a first measurement electrode;
• providing a second measurement electrode within the patient's body;
• using the localization system to determine a location of the second measurement electrode and providing location information data for the second measurement electrode, said location information data comprising position information determined relative to the internal reference location as a reference point;
• taking electrophysiology measurements using each of the first and second measurement electrodes and adjusting the output of the second measurement electrode by compensating for at least one signal that is common to each of the first and second measurement electrodes;
• monitoring for a dislodgement of the local reference from the internal reference location;
• and
• generating a signal indicating that the local reference has dislodged from the internal reference location.