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US 11,761,025 B2Granted
Preservation of cell-free nucleic acids
AssigneeStreck, Inc.
InventorM. Rohan Fernando
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Abstract
A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.
Claims20
A composition for the stabilization of nucleic acids within a plasma sample comprising:
- a. an amount of free formaldehyde;
- b. about 200 to 500 g/L of one or more preservative agents including diazolidinyl urea;
- c. a solvent including water;
- wherein upon mixing the composition with a blood sample and storing the blood sample at room temperature for at least 7 days, cell-free RNA detection is improved due to reduced cellular RNA presence and a reduction in a decrease in cell-free RNA as a result of the composition.
1 more element
Dependencies are inferred from the claim text.