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US 11,760,780 B2Granted
Targeting dimerization of BAX to modulate BAX activity
AssigneeAlbert Einstein College of Medicine
InventorEvripidis Gavathiotis
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Abstract
Methods are provided for identifying an agent that directly modulates a Bcl-2-associated x-protein (BAX) by promoting or disrupting dimerization of the BAX. Agents that directly modulate BAX by affecting dimerization are also provided.
Claims9
A method of inhibiting BCL-2-associated X-protein (BAX) comprising contacting BAX with a peptide consisting of
- a)
- (SEQ ID NO:
- 12)
- TWQTVTIFVAGVLTASLT,
- b)
- (SEQ ID NO:
- 13)
- TWQTVTIFVAGVLTA, or
- c)
- (SEQ ID NO:
- 14)
- TWQTVTIFVAGVL,
- in an amount effective to inhibit BAX.
10 more elements
Dependencies are inferred from the claim text.