Processes and intermediates for preparing MCL1 inhibitors

A method comprising converting a compound of formula 10-B, or a salt thereof to a compound of formula 10-E, or a salt thereof:

• wherein Rp is H;
• wherein Ry is H;
• wherein R2 and R3 are independently H or C1-6alkyl;
• and
• wherein R6 is halogen;
• and
• wherein each Rn is independently C1-6 alkyl, or the two Rn moieties join together to form a C2-4 alkyl bridge, wherein the bridge is optionally substituted by one to four groups independently selected from C1-3alkyl and phenyl.

A method of preparing formula 10-B comprising reacting formula 10-A, or a salt thereof with formula 5-E, or a salt thereof:

• wherein each Rn is independently C1-6 alkyl, or the two Rn moieties join together to form a C2-4 alkyl bridge, wherein the bridge is optionally substituted by one to four groups independently selected from C1-3alkyl and phenyl;
• wherein Rp is H;
• wherein Ry is H;
• wherein R2 and R3 are independently H or C1-6 alkyl;
• and
• wherein R6 is halogen.