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US 11,759,515 B2Granted
Compositions and methods for inducing immune responses
AssigneeArcturus Therapeutics, Inc.
InventorsSean Michael Sullivan, Daiki Matsuda, Kiyoshi Tachikawa, Padmanabh Chivukula, Priya Prakash Karmali, Jared Henry Davis, Yanjie Bao
Life of this patent
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Abstract
Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.
Claims27
A nucleic acid molecule comprising:
- (i) a first polynucleotide encoding one or more viral replication proteins, wherein the first polynucleotide is codon-optimized as compared to a wild-type polynucleotide encoding the one or more viral replication proteins and wherein the first polynucleotide comprises a sequence having at least 80% identity to a sequence of SEQ ID NO:72;
- and
- (ii) a second polynucleotide comprising a first transgene encoding a first antigenic protein or a fragment thereof.
A nucleic acid molecule comprising
- (a) a sequence of SEQ ID NO:78;
- or
- (b) a sequence of SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:76, and SEQ ID NO:77, wherein T is substituted with U.
Dependencies are inferred from the claim text.