Non-invasive assessment of glymphatic flow and neurodegeneration from a wearable device

A head-mounted device comprising:

• a left sensor comprising left electrodes multiplexed to make neurophysiological measurements and neurovascular measurements from a left side of a patient's head;
• a right sensor comprising right electrodes multiplexed to make neurophysiological measurements and neurovascular measurements from a right side of the patient's head;
• and
• a data module operable to:
• receive left side transcranial impedance data from the left sensor,
• receive right side transcranial impedance data from the right sensor, wherein the left and right side transcranial impedance data provide an indication of cranial interstitial fluid flow for the patient wearing the head-mounted device during sleep,
• apply the left and right side transcranial impedance data to a prediction model, the prediction model based upon a function mapping to a target marker of glymphatic flow, and
• output a measure of glymphatic flow.

A brain monitoring system comprising:

• a left sensor comprising left electrodes that make electroencephalogram measurements and transcranial impedance measurements from a left side of a patient's head;
• a right sensor comprising right electrodes that make electroencephalogram measurements and transcranial impedance measurements from a right side of the patient's head;
• and
• a data module that:
• receives left side transcranial impedance data from the left sensor,
• receives right side transcranial impedance data from the right sensor, wherein the left and right side transcranial impedance data provide an indication of cranial interstitial fluid flow for the patient to which the brain monitoring system is attached while the patient is sleeping,
• applies the left and right side transcranial impedance data to a prediction model, the prediction model based upon a function mapping to a target marker of glymphatic flow, and
• outputs a measure of glymphatic flow.