Compositions and methods that modulate phosphorus or enzymes in a companion animal

A method to maintain health and/or body weight of a companion animal, the method comprising:

• administering to the companion animal a pet food composition comprising protein, carbohydrates, fat, fiber, and at least three distinct metabolites;
• the at least three distinct metabolites comprise homocysteine, a first distinct metabolite and a second distinct metabolite, and the pet food composition comprises each of the first and second distinct metabolites in an amount that is (i) about 0.01 wt. % to about 10 wt. % of the pet food composition and/or (ii) about 1 IU to about 500,000 IU per kilogram of the pet food composition;
• wherein the first and second distinct metabolites are each individually selected from the group consisting of erythritol, arabitol, betaine, N-acetylphenylalanine, 3-hydroxybutyrate, citrulline, mannose, 2-oxindole-3-acetate, N-acetyltryptophan, glycerate, xylonate, threitol, 3-aminoisobutyrate, arachidonate, gamma-glutamylphenylalanine, phenylalanine, trigonelline, allantoin, glutathione, N-acetylserine, arabinose, lysine, 3-ureidopropionate, erythronate, gulono-1,4-lactone, C-glycosyltryptophan, urea, 2-hydroxyglutarate, butyrylcarnitine, dimethylglycine, pseudouridine, eicosapentaenoate, uracil, 1-linoleoylglycerophosphoinositol, dihomo-linolenate, phosphate, taurochenodeoxycholate, 15-methylpalmitate, taurocholate, 3-phosphoglycerate, sebacate, stachydrine, citrate, glycolate, campesterol, and mixtures thereof.