Reprogramming cell aging
AssigneeMemorial Sloan Kettering Cancer Center
InventorsLorenz Studer, Daniela Cornacchia
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Abstract
Disclosed herein are methods and compositions for identifying transcriptional and epigenetic age-related markers. Disclosed herein are also methods and compositions for reprogramming cell age by modulating transcriptional and epigenetic age-related markers identified herein. The identified transcriptional and epigenetic age-related markers can also be used for measuring cellular age in a cell or tissue.
Claims9
A method for reprograming cell age, comprising administrating to the cell an epigenetic engineering system, wherein the epigenetic engineering system alters an epigenetic characteristic at a NETO2 gene sequence of the cell.
A method for reprogramming cell age, comprising administrating to the cell a genetic engineering system, wherein the genetic engineering system alters the expression of a NETO2 gene sequence of the cell;
- wherein the genetic engineering system is a CRISPR/Cas9 system, which comprises a Cas9 molecule and a guided RNA (gRNA), wherein the Cas9 molecule is conjugated to a transcription modulator, and the gRNA comprises a targeting domain that is complementary with a target sequence of the NETO2 gene sequence.
Dependencies are inferred from the claim text.