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US 11,753,660 B2Granted
Process for the biological production of methacrylic acid and derivatives thereof
AssigneeMitsubishi Chemical UK Limited
InventorsGraham Ronald Eastham, Gill Stephens, Andrew Yiakoumetti
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Abstract
A process of producing methacrylic acid and/or derivatives thereof including the following steps: (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by the action of an oxidase; and (b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof. The invention also extends to microorganisms adapted to conduct the steps of the process.
Claims8
A microorganism adapted to conduct the following steps:
- (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by expression of a peroxisomal acyl-CoA oxidase from Vigna adiate and/or a short chain acyl-CoA oxidase from Arthrobacter nicotianae;
- and
- (b) biologically converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof.
Dependencies are inferred from the claim text.