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US 11,753,645 B2Granted
Compounds for detecting and treating Mycoplasma hyopneumoniae
AssigneeAerovirus Technologies Inc.
InventorsNorman J Marchand, Thomas G Caltagirone, Albert Liao
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to aptamers, polynucleotides, and nuclei acid molecules, which include a polynucleotide sequence capable of specifically binding polypeptides participating in M. hyopneumoniae infection. Also provided are methods of using nucleic acid molecules, polynucleotides and synthetic antibodies directed there against for detection, treating and neutralization of M. hyopneumoniae infection.
Claims15
A nucleic acid molecule comprising:
- at least one polynucleotide sequence aptamer capable of binding at least one portion of P97, P102, or P116 surface proteins on M. hyopneumoniae,
- wherein the at least one polynucleotide sequence aptamer is selected from the group consisting of:
- APT3Cooc10 (SEQ ID NO:
- 1), APT3Cooc4 (SEQ ID NO:
- 2), APT3Cooc2 (SEQ ID NO:
- 3), APT3Histo1 (SEQ ID NO:
- 4), APT3Cooc3 (SEQ ID NO:
- 5), APT3Histo2 (SEQ ID NO:
- 6), APT3Histo4 (SEQ ID NO:
- 7), APT3Histo5 (SEQ ID NO:
- 8), APT3Histo9 (SEQ ID NO:
- 9), APT3Cooc7 (SEQ ID NO:
- 10), and combinations thereof, and
- wherein the at least one portion is selected from the group consisting of:
- amino acid positions 768 to 1082 of the P97 surface protein (SEQ ID NO:
- 12), amino acid positions 768 to 1050 of the P97 surface protein (SEQ ID NO:
- 24), amino acid positions 768 to 925 of the P97 surface protein (SEQ ID NO:
- 13), amino acid positions 1 to 529 of the P102 surface protein (SEQ ID NO:
- 25), amino acid positions 1 to 324 of the P102 surface protein (SEQ ID NO:
- 26), amino acid positions 651 to 1010 of the P116 surface protein (SEQ ID NO:
- 16), and combinations thereof.
18 more elements
A nucleic acid molecule comprising:
- an aptamer capable of binding P97{535-1028} surface protein (SEQ ID NO:
- 27) on M. hyopneumoniae,
- wherein the aptamer is selected from the group consisting of:
- APT3Cooc10 (SEQ ID NO:
- 1), APT3Cooc4 (SEQ ID NO:
- 2), APT3Cooc2 (SEQ ID NO:
- 3), APT3Histo1 (SEQ ID NO:
- 4), APT3Cooc3 (SEQ ID NO:
- 5), APT3Histo2 (SEQ ID NO:
- 6), APT3Histo4 (SEQ ID NO:
- 7), APT3Histo5 (SEQ ID NO:
- 8), APT3Histo9 (SEQ ID NO:
- 9), APT3Cooc7 (SEQ ID NO:
- 10), and combinations thereof.
11 more elements
A nucleic acid molecule comprising:
- a single stranded DNA aptamer capable of binding P97{768-1082} (SEQ ID NO:
- 12) and/or P97{768-925} (SEQ ID NO:
- 13) surface proteins on M. hyopneumoniae,
- wherein the aptamer is selected from the group consisting of:
- APT3Cooc10 (SEQ ID NO:
- 1), APT3Cooc4 (SEQ ID NO:
- 2), APT3Cooc2 (SEQ ID NO:
- 3), APT3Histo1 (SEQ ID NO:
- 4), APT3Cooc3 (SEQ ID NO:
- 5), APT3Histo2 (SEQ ID NO:
- 6), APT3Histo4 (SEQ ID NO:
- 7), APT3Histo5 (SEQ ID NO:
- 8), APT3Histo9 (SEQ ID NO:
- 9), APT3Cooc7 (SEQ ID NO:
- 10), and combinations thereof.
12 more elements
Dependencies are inferred from the claim text.