Optically controlled virus protein, gene thereof, and virus vector containing said gene
AssigneeThe University of Tokyo
InventorsKenzaburo Tani, Moritoshi Sato, Makoto Takeda, Maino Tahara
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Abstract
The purpose of the present invention is to develop a virus vector, the activity of which is rendered controllable. A virus protein gene derived from an RNA virus is provided in which a gene encoding an optical switch protein is inserted into a foreign gene introducible region of the virus protein so as to enable expression of the gene. By means of this virus vector, it is possible to control, with irradiation of light, enzyme activity of the virus protein and virus vector activity based thereon.
Claims20
A virus protein gene in which a gene coding for an optical switch protein is inserted in an expressible manner in an exogenous gene-transferable region of a virus protein that has an enzyme activity, wherein the optical switch protein comprises at least two subunits, and the nucleic acid sequences encoding for the at least two subunits are linked together via a nucleic acid sequence encoding a linker, or are directly linked together without a linker.
Dependencies are inferred from the claim text.