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US 11,753,371 B2Granted
Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
AssigneeBatterjee Medical College
InventorZiad Omran
Life of this patent
Estimating the term…
Abstract
A disulfiram derivative of formula (I) wherein R1 and R2 are each independently an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, or an optionally substituted heteroarylalkyl, and with the proviso that R1 and R2 are not both ethyl, both benzyl, both —CH2CH2OH, or both A pharmaceutical composition containing the disulfiram derivative of formula (I), and a method of treating ALDH1a1- and/or MAGL-mediated diseases or disorders.
Claims20
A disulfiram derivative of formula (I),
- or a salt thereof, a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof,
- wherein R1 and R2 are each independently,
- wherein the disulfiram derivative has an IC50 for aldehyde dehydrogenase 1a1 (ALDH1a1) in a range of from 0.1 to 25 μM.
A disulfiram derivative of structure
Dependencies are inferred from the claim text.