Apparatus and methods for restoring tissue

A method of tissue restoration in a blood vessel of a subject comprising:

• providing a catheter into the blood vessel, the catheter comprising:
• a catheter shaft extending from a proximal end to a distal tip;
• a plurality of serial balloons positioned on a translucent distal segment of the catheter shaft proximal to the distal tip and positioned inside of and concentric with a distal balloon, the plurality of serial balloons in fluid communication with an inflation source via a first lumen, each of the plurality of serial balloons having a selectively expandable outermost radial surface and each of the plurality of serial balloons comprising:
• a translucent material;
• a series of isolated volumetric regions, one of each of the series of isolated volumetric regions being positioned between adjacent balloons of the plurality of serial balloons and recessed from the outermost radial surfaces of the plurality of serial balloons;
• a plurality of infusion ports, each infusion port being positioned between the plurality of serial balloons
• the distal balloon positioned around the plurality of serial balloons, the distal balloon further comprising a plurality of apertures radially aligned with the isolated volumetric regions of a first distal balloon;
• and
• a light fiber positioned in the catheter shaft and extending through the translucent distal segment;
• supplying a drug from a drug source to the plurality of infusion ports;
• delivering the drug to a treatment area through the plurality of apertures;
• activating the light fiber thereby providing light transmission through the distal segment, the plurality of serial balloons, and the distal balloon to activate the drug in the treatment area.

An apparatus comprising:

• a catheter shaft extending from a proximal end to a distal tip;
• a plurality of serial balloons positioned on a translucent distal segment of the catheter shaft proximal to the distal tip and positioned inside of and concentric with a distal balloon, the plurality of serial balloons in fluid communication with an inflation source via a first lumen, each of the plurality of serial balloons having a selectively expandable outermost radial surface and each of the plurality of serial balloons comprising:
• a translucent material;
• and
• a series of isolated volumetric regions, one of each of the series of isolated volumetric regions being positioned between adjacent balloons of the plurality of serial balloons and recessed from the outermost radial surfaces of the plurality of serial balloons;
• the distal balloon positioned around the plurality of serial balloons;
• and
• a light fiber positioned in the catheter shaft and extending through the translucent distal segment;
• wherein a drug source is configured to provide at least one drug to the distal balloon via the first lumen coincident with inflation of the plurality of serial balloons, and wherein the drug fills between an inside surface of the distal balloon and inflation ports, gradually filling the series of isolated volumetric regions.