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US 11,752,200 B2Granted
Methods of treating neurological disorders
AssigneeEnClear Therapies, Inc.
InventorsManuel A. Navia, Kasper Roet, Jonathan Fleming
Life of this patent
Estimating the term…
Abstract
Disclosed is a method for treating a subject having a neurological disorder characterized by the presence of toxic proteins comprising contacting the cerebrospinal fluid (CSF) of the subject with an agent capable of removing or degrading the toxic protein.
Claims8
A method of treating amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) in a subject, the method comprising:
- contacting the cerebrospinal fluid (CSF) of said subject with trypsin immobilized on an agarose substrate at a concentration of 1-10 milligrams per milliliter, wherein said CSF comprises TDP-43 and said contacting removes TDP-43 from said CSF, thereby treating said subject
- wherein trypsin is immobilized on an agarose substrate in the form of a concentration gradient of 1-10 milligrams per milliliter of trypsin.
A method of treating amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) in a subject, the method comprising:
- contacting the cerebrospinal fluid (CSF) of said subject with elastase immobilized on an agarose substrate at a concentration of 1-10 milligrams per milliliter, wherein said CSF comprises TDP-43 and said contacting removes TDP-43 from said CSF, thereby treating said subject
- wherein elastase is immobilized on an agarose substrate in the form of a concentration gradient of 1-10 milligrams per milliliter of elastase.
Dependencies are inferred from the claim text.