Inhibitor of RNA polymerase II
OwnerCatharina Svanborg, Nina Filenko +1inventors
InventorsCatharina Svanborg, Nina Filenko, Ines Ambite
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Abstract
An inhibitor of RNA polymerase II is described, wherein said inhibitor is selected a moiety which targets a protein selected from cyclin kinase 12 (CDK12) or its recruiting protein PAF1C. Particular examples of such inhibitors are polypeptides expressed by a gene selected from IldD, IldR, nlpD or rfaH of a bacterial species, such as a commensal bacteria or asymptomatic carrier, or a variant of said protein. Inhibitors may be based upon bacterial Sigma S or NplD proteins. These inhibitors are useful in therapies, to suppress protein expression. Thus they may be used as immunosuppressants, anti-inflammatory or anti-infection agents.
Claims15
A method for providing immunosuppression, anti-inflammatory, or anti-infection therapy to a patient in need therefore, the method comprising administering to the patient a pharmaceutical composition comprising an effective amount of an inhibitor of RNA polymerase II, wherein said inhibitor is
- (a) an E. coli NlpD protein;
- or
- (b) an active variant of an E. coli NlpD protein having an amino acid sequence having at least 80% sequence identity to SEQ ID NO:
- 4;
- or
- (c) an E. coli Sigma S protein;
- or
- (d) an active variant of an E. coli Sigma S protein having an amino acid sequence having at least 80% sequence identity to SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3;
- or
- (e) an active fragment of (a), (b), (c), or (d).
Dependencies are inferred from the claim text.