Multiphasic tissue scaffold constructs

A three-dimensional multiphasic synthetic tissue scaffold comprising first, second and third compartments, wherein:

• each said compartment comprises distinct microstructural, chemical, or mechanical properties, and is connected with at least one other compartment of the scaffold via a continuous interface;
• the tissue scaffold is porous;
• and
• the external morphology of the tissue scaffold mimics that of a mammalian joint or a component thereof;
• wherein any one or more of the first, second and/or third compartments comprises:
• a series of fibres;
• or
• a series of fibers comprising multiple fibre layers
• wherein the second compartment comprises a series of fibres mimicking the external morphology of a series of ligaments, and said series of fibres are located intermediate to and connecting the first and third compartments;
• and
• wherein:
• the series of fibres in the second compartment comprise first and second fibre layers,
• the first fibre layer is aligned along a first axis,
• the second fibre layer is aligned along a second axis, and
• the second axis is rotated at an angle relative to the first axis.