Chalcone-based chemotherapeutic compound for triple negative breast cancer
AssigneeQatar University
InventorsAshraf Khalil, Ala-Eddin Al Moustafa, Dana H. Elkhalifa, Feras Alali
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Abstract
Provided herein are compounds, compositions, and methods useful for the treatment of breast cancer, particularly triple negative breast cancers. In certain aspects, provided herein are compounds of formula (I): or a pharmaceutically acceptable salt or solvate thereof. In certain aspects, provided herein are compositions comprising any of the compounds provided herein. In certain aspects, provided herein are methods for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of any of the compounds or compositions provided herein.
Claims12
A compound of formula I:
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein
- R1 and R2 are each independently haloalkyl;
- R4 is selected from chloro, methylsulfonyl, methylthio, methoxy, piperazinyl, pyrrolidyl, morpholinyl, and piperidyl;
- and
- R3, R5, R6, and R7 are each hydrogen.
A compound selected from the following:
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.