Synthetic method and application of 2-hydroxyphenyl-5-pyrazinyl ketone

A method of synthesizing a 2-hydroxyphenyl-5-pyrimidine ketone represented by a chemical formula (I), comprising:

• weighing 0.048 g of a palladium complex, 0.8413 g of chromone-3-formaldehyde and 2.5719 g of ammonium formate into a 100 mL round bottom flask, then adding 50 mL of anhydrous methanol to dissolve, heating to reflux for 36 h, then stopping the reaction, performing column chromatography with petroleum ether and dichloromethane in a volume ratio of 1:1, and then naturally volatilizing a first component to obtain a light yellow crystal, namely the 2-hydroxyphenyl-5-pyrimidine ketone;
• wherein the chemical formula (I) is as follows:
• and
• the light yellow crystal has crystal data as follows:
• orthorhombic system, a space group of P 21 21 21;
• unit cell parameters are a=5.505 (2) Å α=90°;
• b=11.343(10) Å β=90°;
• c=14.796(13) Å γ=90°, obtained by collecting diffraction data at a temperature of 273(2) K on an Oxford X-ray single crystal diffractometer using ω-θ scanning with CuKα rays 0.71073 Å, which is monochromatized by a graphite monochromator.