Compositions, methods, and systems for the synthesis and use of imaging agents
AssigneeLantheus Medical Imaging, Inc.
InventorsRichard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson
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Abstract
The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
Claims19
A cassette for the preparation of an imaging agent comprising a linear arrangement of a plurality of stopcock manifolds arranged in the order:
- 1) ethanol reservoir;
- 2) syringe with a solution of ascorbic acid or salt thereof;
- 3) syringe with water;
- and
- 4) final product vial;
- wherein the imaging agent is of the formula:
An apparatus for synthesizing an imaging agent comprising a linear arrangement of a plurality of stopcock manifolds arranged in the order:
- 1) ethanol reservoir;
- 2) syringe with solution of ascorbic acid or salt thereof;
- 3) syringe with water;
- 4) final product vial.
An apparatus for synthesizing an imaging agent comprising a linear arrangement of a plurality of stopcock manifolds arranged in the order:
- 1) ethanol reservoir;
- 2) final product vial;
- 3) syringe with water;
- and
- 4) syringe with solution of ascorbic acid or salt thereof.
Dependencies are inferred from the claim text.