Phage conjugates and uses thereof
AssigneeConsiglio Nazionale Delle Ricerche
InventorsPiergiuseppe De Berardinis, Rossella Sartorius
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.
Claims16
A pharmaceutical composition comprising lipid-bacteriophage conjugates, wherein the bacteriophage is conjugated to at least one lipid by means of a non-covalent bond and the bacteriophage lipid ratio is between 3:1 and 100:1;
- wherein the lipid is selected from the group consisting of alpha-galactosylceramide (aGalCer), glycosphingolipids, palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC), monophosphoryl lipid A and their natural or synthetic analogues and the bacteriophage is a filamentous bacteriophage.
Dependencies are inferred from the claim text.